Studies of the nuclear many-body system. Nuclear structure and interactions, nuclear reactions in astrophysics, nuclear matter under extreme conditions, precision measurements of critical information to nucleosynthesis along the r- and rp-process paths. Low-energy experiments in fundamental interactions and symmetries. Production, cooling and trapping of rare isotopes, R&D for the Rare Isotope Accelerator (RIA) project. Non-nucleonic degrees of freedom in nuclei and phenomena requiring a quark description. Coherent nuclear scattering. Exotic nuclear structure.